Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC002
Sex MALE
Dominant hand LEFT
Test date and time 2021-11-05 11:19
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment

th tbl Madopar 250mg 3x1/

caps Madopar HBS 125mg rigor forma

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 26 individuals with a value less than 0.61 were subsequently diagnosed with PD. That is, 61.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.61 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 10, 'TN': 11, 'TP': 32, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 17, 'TP': 19, 'FP': 13}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 17, 'TN': 10, 'TP': 25, 'FP': 20}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 14.588
timePerCircleCoV 0.137239
timePerCircleSlope -0.0394014
meanError 1.0608
tremorFreq 9.86328
tremorRelPower 18.3874
tremorGyroAmpMean 0.0115266
tremorGyroAmpSlope 0.0072456
tremorGyroAmpCoV 0.384211
tremorCoordAmpMean 0.0356258
tremorCoordAmpSlope 0.00464256
tremorCoordAmpCoV 0.34508
tremorAccAmpMean 0.0225714
tremorAccAmpSlope 0.00476876
tremorAccAmpCoV 0.264616
tremorPcRelVar 0.612533
tremorPcX -0.532271
tremorPcY -0.846574

Circle Segment 1

Duration 19.08 s, Accuracy Estimate 0.833 (lower is better)

Circle Segment 2

Duration 15.36 s, Accuracy Estimate 0.757 (lower is better)

Circle Segment 3

Duration 15.72 s, Accuracy Estimate 0.843 (lower is better)

Circle Segment 4

Duration 15.72 s, Accuracy Estimate 0.789 (lower is better)

Circle Segment 5

Duration 13.16 s, Accuracy Estimate 0.966 (lower is better)

Circle Segment 6

Duration 14.16 s, Accuracy Estimate 1.007 (lower is better)

Circle Segment 7

Duration 14.2 s, Accuracy Estimate 0.829 (lower is better)

Circle Segment 8

Duration 13.64 s, Accuracy Estimate 1.004 (lower is better)

Circle Segment 9

Duration 12.6 s, Accuracy Estimate 0.926 (lower is better)

Circle Segment 10

Duration 12.24 s, Accuracy Estimate 2.653 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 30.588
timePerSpiralCoV 0.101736
timePerSpiralSlope -0.0155101
meanError 1.44154
tremorFreq 9.66797
tremorRelPower 22.2535
tremorGyroAmpMean 0.0138582
tremorGyroAmpSlope 0.0013436
tremorGyroAmpCoV 0.455078
tremorCoordAmpMean 0.0552129
tremorCoordAmpSlope 0.0010502
tremorCoordAmpCoV 0.448789
tremorAccAmpMean 0.045893
tremorAccAmpSlope 0.000506318
tremorAccAmpCoV 0.168641
tremorPcRelVar 0.603064
tremorPcX 0.763355
tremorPcY 0.64598

Spiral Segment 1

Duration 34.68 s, Accuracy Estimate 1.514 (lower is better)

Spiral Segment 2

Duration 29.48 s, Accuracy Estimate 1.395 (lower is better)

Spiral Segment 3

Duration 29.56 s, Accuracy Estimate 1.554 (lower is better)

Spiral Segment 4

Duration 32.56 s, Accuracy Estimate 1.42 (lower is better)

Spiral Segment 5

Duration 32.92 s, Accuracy Estimate 1.527 (lower is better)

Spiral Segment 6

Duration 32.96 s, Accuracy Estimate 1.531 (lower is better)

Spiral Segment 7

Duration 25.52 s, Accuracy Estimate 1.328 (lower is better)

Spiral Segment 8

Duration 29.92 s, Accuracy Estimate 1.387 (lower is better)

Spiral Segment 9

Duration 32.52 s, Accuracy Estimate 1.368 (lower is better)

Spiral Segment 10

Duration 25.76 s, Accuracy Estimate 1.391 (lower is better)

Elel

eDurationMean 0.736021
eDurationStd 0.265297
eDurationStdnorm 0.360448
eDurationMedian 0.70252
eDurationQuartdelta 0.202506
eDurationQuartdeltanorm 0.288256
eDurationKurt 12.5771
eDurationTrenddiff -0.147504
eDurationTrendratio 0.809061
eWidthMean 6.21467
eWidthStd 1.33752
eWidthStdnorm 0.21522
eWidthMedian 6.0255
eWidthQuartdelta 1.6965
eWidthQuartdeltanorm 0.281553
eWidthKurt 3.30489
eWidthTrenddiff -0.948268
eWidthTrendratio 0.854242
eHeightMean 10.9265
eHeightStd 1.9859
eHeightStdnorm 0.181752
eHeightMedian 10.647
eHeightQuartdelta 2.92486
eHeightQuartdeltanorm 0.274712
eHeightKurt 3.15616
eHeightTrenddiff -2.1645
eHeightTrendratio 0.818627
eAspectMean 0.573703
eAspectStd 0.0951217
eAspectStdnorm 0.165803
eAspectMedian 0.564482
eAspectQuartdelta 0.119487
eAspectQuartdeltanorm 0.211676
eAspectKurt 3.17134
eAspectTrenddiff -0.00664608
eAspectTrendratio 0.988271
eSlantMean 0.27551
eSlantStd 0.106794
eSlantStdnorm 0.387625
eSlantMedian 0.260883
eSlantQuartdelta 0.119905
eSlantQuartdeltanorm 0.459613
eSlantKurt 4.12284
eSlantTrenddiff 0.0265353
eRtopMean 0.821981
eRtopStd 0.0854485
eRtopStdnorm 0.103954
eRtopMedian 0.836052
eRtopQuartdelta 0.126279
eRtopQuartdeltanorm 0.151043
eRtopKurt 2.2521
eRtopTrenddiff 0.0534436
eRbotMean 0.349175
eRbotStd 0.109444
eRbotStdnorm 0.313436
eRbotMedian 0.345344
eRbotQuartdelta 0.127245
eRbotQuartdeltanorm 0.368458
eRbotKurt 4.15546
eRbotTrenddiff -0.0226283
eRrightMean 0.889035
eRrightStd 0.0615065
eRrightStdnorm 0.0691834
eRrightMedian 0.898927
eRrightQuartdelta 0.0761159
eRrightQuartdeltanorm 0.0846742
eRrightKurt 3.18802
eRrightTrenddiff -0.00855939
eRleftMean 0.212185
eRleftStd 0.0957684
eRleftStdnorm 0.451344
eRleftMedian 0.193885
eRleftQuartdelta 0.120189
eRleftQuartdeltanorm 0.6199
eRleftKurt 3.50745
eRleftTrenddiff -0.0100061
lDurationMean 1.14003
lDurationStd 0.287214
lDurationStdnorm 0.251935
lDurationMedian 1.06753
lDurationQuartdelta 0.217506
lDurationQuartdeltanorm 0.203747
lDurationKurt 10.939
lDurationTrenddiff -0.142504
lDurationTrendratio 0.875817
lWidthMean 11.2452
lWidthStd 1.34353
lWidthStdnorm 0.119476
lWidthMedian 11.5245
lWidthQuartdelta 1.59224
lWidthQuartdeltanorm 0.138161
lWidthKurt 3.61828
lWidthTrenddiff -0.6435
lWidthTrendratio 0.945274
lHeightMean 27.7062
lHeightStd 3.38255
lHeightStdnorm 0.122087
lHeightMedian 27.612
lHeightQuartdelta 5.66139
lHeightQuartdeltanorm 0.205034
lHeightKurt 2.46532
lHeightTrenddiff -4.72271
lHeightTrendratio 0.840138
lAspectMean 0.409363
lAspectStd 0.0519724
lAspectStdnorm 0.126959
lAspectMedian 0.419042
lAspectQuartdelta 0.0478774
lAspectQuartdeltanorm 0.114254
lAspectKurt 4.6894
lAspectTrenddiff 0.0270228
lAspectTrendratio 1.0684
lSlantMean 0.253581
lSlantStd 0.0740748
lSlantStdnorm 0.292116
lSlantMedian 0.274732
lSlantQuartdelta 0.0861457
lSlantQuartdeltanorm 0.313563
lSlantKurt 5.5036
lSlantTrenddiff 0.0455253
lRtopMean 0.890382
lRtopStd 0.0569101
lRtopStdnorm 0.0639165
lRtopMedian 0.898268
lRtopQuartdelta 0.0620413
lRtopQuartdeltanorm 0.0690677
lRtopKurt 2.98516
lRtopTrenddiff 0.0159462
lRbotMean 0.282678
lRbotStd 0.119968
lRbotStdnorm 0.424399
lRbotMedian 0.252216
lRbotQuartdelta 0.098034
lRbotQuartdeltanorm 0.38869
lRbotKurt 6.67041
lRbotTrenddiff -0.0376667
lRrightMean 0.929402
lRrightStd 0.0348064
lRrightStdnorm 0.0374503
lRrightMedian 0.933403
lRrightQuartdelta 0.0401158
lRrightQuartdeltanorm 0.042978
lRrightKurt 3.37233
lRrightTrenddiff 0.00297424
lRleftMean 0.150286
lRleftStd 0.0604258
lRleftStdnorm 0.402071
lRleftMedian 0.133353
lRleftQuartdelta 0.0711765
lRleftQuartdeltanorm 0.533745
lRleftKurt 4.54195
lRleftTrenddiff -0.0232017

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.979474
sumTouchScores 22.5279
meanMovementTime 0.8075
numTouches 23
undershootPercentage 4.34783
overshootPercentage 4.34783

FITTS Long Modified

meanTouchScore 0.927305
sumTouchScores 13.9096
meanMovementTime 0.87
numTouches 15
undershootPercentage 6.66667
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 24.296
timePerZigzagCoV 0.153904
timePerZigzagSlope -0.0544946
meanError 2.11786
tremorFreq 9.57031
tremorRelPower 20.033
tremorGyroAmpMean 0.0181735
tremorGyroAmpSlope 0.000196257
tremorGyroAmpCoV 0.41618
tremorCoordAmpMean 0.0671662
tremorCoordAmpSlope 0.00283628
tremorCoordAmpCoV 0.397784
tremorAccAmpMean 0.0384466
tremorAccAmpSlope 0.00114932
tremorAccAmpCoV 0.277741
tremorPcRelVar 0.818897
tremorPcX 0.130176
tremorPcY 0.991491

ZigZag Segment 1

Duration 28.96 s, Accuracy Estimate 1.714 (lower is better)

ZigZag Segment 2

Duration 21.04 s, Accuracy Estimate 2.222 (lower is better)

ZigZag Segment 3

Duration 25.68 s, Accuracy Estimate 1.972 (lower is better)

ZigZag Segment 4

Duration 25.88 s, Accuracy Estimate 1.98 (lower is better)

ZigZag Segment 5

Duration 19.92 s, Accuracy Estimate 2.701 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 19.68
timePerZigzagCoV 0.060755
timePerZigzagSlope -0.0243902
zigzagHeightMean 60.2517
zigzagHeightCoV 0.0486061
zigzagHeightSlope 0.0269954
meanError 0.0337508
tremorFreq 8.88672
tremorRelPower 33.0095
tremorGyroAmpMean 0.0256169
tremorGyroAmpSlope 0.00325758
tremorGyroAmpCoV 0.444492
tremorCoordAmpMean 0.106828
tremorCoordAmpSlope 0.00211768
tremorCoordAmpCoV 0.35282
tremorAccAmpMean 0.0483278
tremorAccAmpSlope 0.00307159
tremorAccAmpCoV 0.456713
tremorPcRelVar 0.857023
tremorPcX 0.156487
tremorPcY -0.98768

ZigZag Offset Segment 1

Duration 21.4 s, Accuracy Estimate 0.019 (lower is better)

ZigZag Offset Segment 2

Duration 20.16 s, Accuracy Estimate 0.021 (lower is better)

ZigZag Offset Segment 3

Duration 18.2 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 4

Duration 19.12 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 5

Duration 19.52 s, Accuracy Estimate 0.06 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.71}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.61}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.08625732553823084}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.683014975970512}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}